An evolved strain of Lactobacillus acidophilus deposited with the DSMZ under number DSM 33463 on 4 Mar., 2020 (NCFM 6.3).ġ0.

A heat evolved strain of Lactobacillus acidophilus NCFM wherein the strain has at least one mutation selected from the group consisting of: a) at least one mutation in a gene that encodes a 30S ribosomal protein S18 (rpsR) b) at least one mutation in a gene that encodes a pyridoxal kinase (LBA1007) c) at least one mutation in a gene that encodes an ATPase (clpC) d) at least one mutation in a gene that encodes a gnt transcriptional regulator (gntR) and e) at least one mutation in an intergenic region that affects the expression of the gene encoding uridine monophosphate kinase (LAB1268) f) at least one mutation in a gene encoding a cation transporter (LBA0098) and g) at least one mutation in a gene encoding a transposase (LBA0127) wherein the mutations of a)-g) are as compared with the genome sequence of the parental strain ( Lactobacillus acidophilus NCFM, ATCC 700396), SEQ ID NO:2 and wherein the evolved strain has greater storage stability as compared with the parental strain ( Lactobacillus acidophilus NCFM, ATCC 700396).ĩ.

Lactis deposited with the DSMZ under number DSM 33461 on 4 March, 2020 (BBi 6.6).Ħ. A heat evolved strain of Bifidobacterium animalis subsp. A heat evolved strain of Bifidobacterium wherein the strain has at least one mutation selected from the group consisting of: a) at least one mutation in the gene encoding a Polyribonucleotide nucleotidyltransferase b) at least one mutation in the CheY-like receiver domain c) at least one mutation in the gene encoding a SSU ribosomal protein d) at least one mutation in the intergenic regions upstream of the gene encoding an Oleate hydratase and downstream of the gene encoding a Phosphoglycerate mutase e) at least one mutation in the gene encoding a Pup ligase PafA' paralog f) at least one mutation in the gene encoding a UTP-glucose-1-phosphate uridylyltransferase g) at least one mutation in the gene encoding an Arginine/ornithine antiporter ArcD and h) at least one mutation in the gene encoding a Pyridoxine biosynthesis glutamine amidotransferase, wherein the mutations described in parts a)-h) are as compared with the genome sequence of the ancestral strain as set forth in SEQ ID 1, and wherein the evolved strain has greater storage stability or effective productivity as compared with the ancestral strain (Bi-07, ATCC PTA SD5220).ĥ. VWR will support you from the latest life science products to the guaranteed purity of organic building blocks.1. A strong, vibrant research and development group is the lifeblood of all industries.

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